ea0029p990 | Growth hormone IGF axis - basic | ICEECE2012
Mitsuishi M.
, Miyashita K.
, Muraki A.
, Tamaki M.
, Tanaka K.
, Itoh H.
Aim: We investigated the influence of mitochondrial dysfunction associated with aging on physical performance in mice, and the effect of hormone replacement on physical performance.Method: Using 8, 20, 50 and 100 week-old C57bl6 mice, we evaluated skeletal muscle mass, mitochondrial activity, glucose tolerance and physical performance (muscle power and exercise endurance). In addition, we treated 50-week-old mice with ghrelin or insulin like growth facto...